Combining oral, antidiabetic drugs with insulin is an appropriate treatment for some people with Type 2 diabetes. Sometimes, this type of regime is transitory and the person may eventually transfer to insulin alone. In other cases, combination therapy may be continued for some considerable time. Two types of antidiabetic drug (sulphony-lureas and metformin) are most commonly combined with insulin.
- Sulphonylureas and Insulin
Usually, sulphonylureas are taken during the day and cloudy insulin (isophane) is injected at night or in the morning. The results of some studies suggest that half the normal insulin dose is sufficient with this combination, at least in the initial stages of treatment.
- Metformin and Insulin
Once again, metformin is taken during the day and cloudy (isophane) insulin is injected at night and/or in the morning. Studies suggest that there is a lower risk of weight gain with this regime compared to insulin therapy alone, in Type 2 diabetes. It may also provide better control of blood glucose levels than twice-daily insulin alone. It is thought to be a particularly suitable therapy for overweight people with Type 2 syndrome, in whom further weight gain is obviously undesirable.
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